Codex Chisianus 45 is a significant manuscript for the study of the Septuagint, particularly for its preservation of the Old Greek (OG) text of the Book of Daniel.
The OG text of Daniel largely disappeared from Greek tradition by the end of the 4th century, having been superseded by Theodotion's revision, which was endorsed by prominent figures such as Jerome.
These deviations include transpositions, expansions, abridgements, and modifications that occasionally alter the prophetic messages.
Irish scholar John Gwynn, writing in 1911, offered a critical assessment of the translation of Daniel found in Codex Chisianus, remarking: Indeed, the greater part of this Chisian Daniel cannot be said to deserve the name of a translation at all.
It deviates from the original in every possible way; transposes, expands, abridges, adds or omits, at pleasure.