Coisogenic strain

[1][2] Coisogenic strains can be used to investigate the function of a certain genetic locus.

Coisogenic strains can be induced chemically or through radiation however, other types of alterations within the genome may also occur.

This backcrossing is then continued until more than 99% is genetic background and the mutated locus is inherited.

[3] However, if the specific mutation cannot be passed on, heterozygous animals should be used to breed with the original inbred strain.

Full-sib mating are used to maintain coisogenic strains if the specific gene locus is homozygous.