Cokesbury is a census-designated place (CDP) in Greenwood County, South Carolina, United States.

According to the United States Census Bureau, the Cokesbury CDP has a total area of 0.58 square miles (1.5 km2), all land.

There were 111 housing units at an average density of 176.7 per square mile (68.2/km2).

25.7% of all households were made up of individuals, and 7.6% had someone living alone who was 65 years of age or older.

About 7.4% of families and 13.5% of the population were below the poverty line, including none of those under the age of eighteen and 51.7% of those 65 or over.