In the same year, it also merged with Coleg Llysfasi, in Ruthin, Denbighshire, forming one of Wales' largest institutions with almost 22,000 annual students and 1000 staff.

[1] Its location close to the England–Wales border, gave the college a catchment area of not just Flintshire, but also the Wirral and the Cheshire–South Lancashire urban conurbations.

[2] In 1944, during the increasing industrialisation of Flintshire, the Advisory Council for Technical Education (North Wales) was set up.

The excess capacity was preparation for the Mid-20th century baby boom and for children born of that period reaching 16.

[3] Issues arose from the 1950s, over competition with the nearby Denbighshire Technical College, in Wrexham, as they were only 17 miles (27 km) apart.

[2] A 1958 report, into the overlapping of two colleges, recommended that all advanced education courses, aside from metallurgy, be based in Wrexham.

Particularly its advanced chemistry courses, which the Flintshire authority rejected to withdraw and continued to provide them against the panel's recommendation.

[3] On 6 October 1998, the Deeside College Sports Stadium was opened by Ron Davies, Secretary of State for Wales.

From 2000 to 2002, the college set up learning centres in local companies such as Airbus UK, Castle Cement, Corus Colors and Merloni Elettrodomestici, as part of partnerships to improve employees' access to education.

[4] In June 2003, the £8 million Deeside College Centre of Engineering Excellence was opened by Queen Elizabeth II.

[10] By 2011, the group formed one of Wales' largest institutes, encompassing the three colleges, and having almost 22,000 students annually,[1] over 1000 staff and almost £40 million in income.

[3] In the same year, Cheryl Gillan, Secretary of State for Wales, described the college as "the best in the UK" and encouraged more businesses to relocate to Flintshire.

[18] In 2015, Coleg Cambria announced plans to build a Higher Education centre on the Connah's Quay campus.

[20] In August 2024, Coleg Cambria opened a £230,000 Esports arena on the Connah's Quay campus and is one of a few further education gaming complexes in the country.

[23] The campus hosted, in 2010, the North Wales Indoor Athletics Centre (opened in 2005[24]), a multisports hall, the Deeside Stadium, a gym, hair, beauty and therapy salons, as well as a cafe, restaurant and bar.

[6] The stadium contains a full-size football pitch, a running track, and is home to the Connah's Quay Nomads F.C.

On 6 July 1962, seven-lane athletics cinder track, costing more than £5,000, was opened as the college hosted the North Wales AAA Championships.

[20] It hosts studios, labs and suites for art, product design, drama, science and ICT.