Collège Sainte-Marie (French pronunciation: [kɔlɛʒ sɛ̃t maʁi]) was a college in Montreal, Quebec, Canada.

It ceased to exist in 1969, when it was merged into UQAM (Université du Québec à Montréal).

It relied on its affiliation with chartered universities to grant degrees but had full curriculum control.

Built in 1865 and designed by Irish architect Patrick Keely, it is one of the oldest religious buildings in Montreal.

[1] Also housed in the structure is the Salles du Gesù, Montreal's oldest theatre.