[2] More recent studies indicate that Colobomycter is properly placed within the amniote clade Parareptilia, as part of the group Lanthanosuchoidea and closely related to the taxon Acleistorhinus.

[3][4] Other taxa recovered from these strata preserves a wide array of tetrapods, including lepospondyl and temnospondyl amphibians, Seymouria, microsaurs, captorhinomorphs, and synapsids.

The skull of Colobomycter is considered one of the most enigmatic found in any of the parareptiles primarily due to the presence of greatly enlarged caniniform teeth possessing serrated edges in the premaxilla and, to a lesser extent, the maxilla.

The taxon also possesses unusual "folding" of the dentine at the bases of its larger marginal teeth, a state known as polyplycodont (a condition also seen to have evolved independently in diadectomorphs, ichthyosaurs, and mosasaurs).

[7] Modesto & Reisz (2008) speculate that hard-shelled insects and other arthropods may have formed the bulk of its diet, but that Colobomycter could also have fed on vertebrates, including small amphibians and eureptiles.