Colombier-Saugnieu (French pronunciation: [kɔlɔ̃bjesoɲø]) is the easternmost commune in the Rhône department, on the border with Isère, in the Auvergne-Rhône-Alpes region in central-eastern France.

The river Bourbre forms part of the commune's eastern border.

Lyon-Saint-Exupéry TGV station and most of Lyon–Saint-Exupéry Airport (a small part in the north is in Pusignan) are in the commune.

It is part of the public transport zone of Rhônexpress, although the rail link does not serve the villages of Colombier (which houses the town hall), Saugnieu and Montcul east of the airport.

The commune has a primary school, the Groupe Scolaire Jules Ferry.