Crossover Ministries, an organization that travels internationally to teach basketball and minister to young people all over the world, took the reins of the franchise less than two months before the season was to begin.

The Crossover began play on March 31, 2006, losing a hard-fought game at their in-state rivals, the Aurora Cavalry, 140–132, the first of many spirited battles between the teams.

The Colorado Crossover finished their inaugural season next to last place in the Western Conference, but earned a reputation for playing teams tough throughout their games and occasionally knocking off top contenders in the league.

What resulted was a dramatic improvement on their inaugural season, led by scoring leaders Phillip Hillstock and Darius Pope.

It started with a 170–146 victory over the Lewis County Raptors at home, scoring the second-highest single game total in Colorado pro basketball history and highest ever in regulation, with 92 points in the first half alone.