SH 144 begins in the west at I-76 and proceeds initially to the north; after 2.8 mi (4.5 km), the road crosses U.S. Route 34 (US 34).

After another 3.8 mi (6.1 km), the route crosses the South Platte River and begins to curve in a broad arc to the east roughly following a meander of the South Platte.

The road then continues its arc eastward and eventually ESE through Weldona, again across the South Platte River, and through Log Lane Village.

Now traveling in approximately a southeasterly direction, SH 144 crosses to the south side of I-76 and continues for a further 1.4 mi (2.3 km) to its eastern terminus at SH 52 in Fort Morgan.

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