SH 368 begins at a junction with SH 370 and County Road 4E (CR 4E) in Rio Grande County, about 3.8 miles (6.1 km) west of Waverly and approximately 11 miles (18 km) southeast of Monte Vista.

CR 4E heads north toward the Monte Vista National Wildlife Refuge.

Continuing due south for about another one mile (1.6 km), SH 368 curves to head due east, with a junction with the north end of County Road 10 in the middle of the curve at a T intersection.

)[2] From its junction with SH 371 and CR DD, SH 368 heads due east into Alamosa County for approximately 6.3 miles (10.1 km) to its western terminus with US 285 and Alamosa County Road 14S (CR 14S) in Estrella, connecting with the south end of several county roads along the way.

)[2] Media related to Colorado State Highway 368 at Wikimedia Commons