The refined and masterful classical Latin of his letters to Florentine scholars earned him the admiring nickname of "Ape of Cicero",[2] In 1367 Coluccio was appointed chancellor of Todi in the Papal States.
Florence's principal nemesis during his tenure, Gian Galeazzo Visconti, Duke of Milan, once remarked that one of Salutati's letters could "cause more damage than a thousand Florentine horsemen.
His treatise De tyranno ("On the tyrant") published in 1400, has, most likely, its model in Visconti, although in it Salutati (despite being a republican) remains a supporter of the providential universal monarch already put forward by Dante.
When he wrote to the people of Ancona in 1376, inciting them, in the name of their freedom, to revolt against the governor imposed by the pope, he called to mind the evils Italy had suffered on behalf of the French.
A skilled writer and orator, Coluccio drew heavily upon the classical tradition and developed a powerful prose style based on the Latin of Virgil and Cicero: "I have always believed," Salutati wrote, "I must imitate antiquity not simply to reproduce it, but in order to produce something new".
By bringing Chrysoloras to Florence, Salutati made it possible for a select group of scholars (including Bruni and Vergerio) to read Aristotle and Plato in the original ancient Greek.