[3] In a letter to Poggio Bracciolini, quoting the Roman lawyer and statesman Cicero, Salutati wrote: Chrysoloras arrived in the winter of 1397, an event remembered by one of his most famous pupils, the Italian humanist scholar Leonardo Bruni,[1] as a great new opportunity: there were many teachers of law, but no one had studied Greek in northern Italy for 700 years.

[1] Aside from Bruni, d'Angelo, and Ambrogio Traversari, they included Guarino da Verona, Coluccio Salutati, Roberto Rossi, Niccolò de' Niccoli, Carlo Marsuppini, Pier Paolo Vergerio, Uberto Decembrio, Palla Strozzi, and many others.

In 1413, he went to Germany on an embassy to the Holy Roman Emperor Sigismund, the object of which was to fix a place for the church council that later assembled at Constance.

His own works, which circulated in manuscript in his lifetime, include brief works on the Procession of the Holy Ghost, and letters to his brothers, to Bruni, Guarino, Traversari, and to Strozzi, as well as two which were eventually printed, his Erotemata (Questions) which was the first basic Greek grammar in use in Western Europe, first published in 1484 and widely reprinted, and which enjoyed considerable success not only among his pupils in Florence, but also among later leading humanists, being immediately studied by Thomas Linacre at Oxford and by Desiderius Erasmus at Cambridge; and Epistolæ tres de comparatione veteris et novæ Romæ (Three Letters on the Comparison of Old and New Rome, i.e. a comparison of Rome and Constantinople).

He was chiefly influential through his teaching in familiarizing men such as Leonardo Bruni, Coluccio Salutati, Jacopo d'Angelo, Roberto de' Rossi, Carlo Marsuppini, Pietro Candido Decembrio, Guarino da Verona, with the masterpieces of Western philosophy and ancient Greek literature.