In 1898, the school moved to its first exclusive building (a two-story, red brick structure) at 11th Street and 4th Avenue and remained at that location until 1927.

In 1923, the “Blue Devil” name was first used when General John J. Pershing referred to a spirited football team playing against Phillips High School in Birmingham, Alabama.

Previous to that time, several nicknames had been used for CHS sports teams, one of them was “Orange Avalanche.”[4] In 1924, a bond referendum was approved to build a new high school.

The 11th street location had become too small to accommodate the growing population of the city, especially after Camp Benning (now Fort Moore) brought an influx of new people to Columbus during and following World War I. Sixteen acres in Wildwood Park was selected as the site for the new location for Columbus High School.

The respected New York Architectural firm of Starrett and van Vleck, working with local architects, designed the building and the surrounding area.

[6] CHS students have a college readiness index of 85.8%, with Mathematics and English proficiencies at 88 and 84 percents, respectively - more than twice the state average.

[3] All Liberal Arts College Preparatory Magnet students entering the program as 9th graders must earn a total of 32 Carnegie units.

Each year, freshmen, sophomores, and juniors complete 20 hours of community service with a local non-profit organization.

[8] The senior project requires students to pick an activity they have never tried before, work 50 hours alongside a mentor, and maintain a portfolio documenting their progress from the summer before senior year up until the final presentation at Board's Night (usually in April) when they present their project to a panel of judges.

At CHS the drama department or "Full House Productions" usually produces a one-act show that is used to compete in a local competition, and a spring musical.