St. Anne-Pacelli Catholic School is named for Saint Anne, the mother of the Virgin Mary, and Pope Pius XII (Eugenio Pacelli).

In 1868, the Sisters of Mercy purchased a home in Downtown Columbus, Georgia and converted it into a convent.

[2] Until St. Anne Church was built in 1961, the school operated under the name Holy Family School, and was operated by the Church of the Holy Family.

Middle and high school athletes compete in 14 sports.

At the varsity level, St. Anne-Pacelli competes as a Single A member of the Georgia High School Association (GHSA).