Patrick J. Sowers, Robert T. Tranter, David Mueller and his father Raymond founded the airline in Cincinnati.

At the end of its first year of highly profitable operations, two of the company founders, Sowers and Tranter, abruptly resigned the day following the first annual meeting as a "demand for immediate change" after they had uncovered repeated unacceptable and unsafe operational practices by one of the other partners.

[3] In 1992, Comair moved into Concourse C at CVG, as Delta Air Lines gradually continued to acquire more of the airlines stock.

By 1999, Comair was the largest regional airline in the country worth over 2 billion, transporting 6 million passengers yearly to 83 destinations on 101 aircraft.

[7] The strike ended 89 days later, in June, after the pilots approved a contract that included pay raises.

On December 23 and 24, a record snowfall hit the Cincinnati area, forcing the airline to deplete its entire supply of deicing solution.

With the area highways closed due to the blizzard, no additional deicing fluid could be delivered to the airport, and Comair was forced to cancel all flights beginning on Friday December 24.

After receiving necessary supplies overnight, the airline began the process of startup when the computer system that handled flight crew assignments shut down.

It had been designed with a hard coded limit of changes for a month, which were far exceeded due to the poor weather in the prior days.

[citation needed] In late 2006, Comair opened an additional crew base and hub at New York City's JFK Airport.

This was the result of starting operations at JFK, a congested airport with poor staffing and an unfortunate terminal and aircraft ramp layout that severely dropped Comair's ratings in the DOT listings.

[13] [needs update] On September 1, 2010, Comair announced that it would reduce its fleet by eliminating all of its aging Bombardier CRJ100/200 aircraft, expecting to have retired them all sometime in 2012.

[15] Comair operated passenger services to 83 destinations in the United States, Canada, Mexico and the Bahamas at its peak in 2005.

[1] Before its downsizing, Comair operated the largest number of Bombardier (formerly Canadair) regional jets of any airline with over 170 planes.