[2] It fed United Airlines flights at Chicago O'Hare International Airport (ORD) and Houston George Bush Intercontinental Airport (IAH) under the United Express brand, as well as Delta Air Lines flights at Atlanta (ATL), New York-LaGuardia (LGA), and New York-JFK under the Delta Connection brand.

Shuttle America was established in 1995 by former CEO David Hackett, and began operations on November 12, 1998,[3] as a low-fare commuter airline, headquartered in Windsor Locks, Connecticut, the location of Hartford's Bradley International Airport.

Shuttle America's first aircraft; registered N801SA, was a 50-seat Bombardier Dash 8-300 with leather seats and a very creative and patriotic paint scheme.

Located in Bedford, Massachusetts, just 12 miles (19 km) west of Boston, it had amenities not found at the larger Logan Airport.

At the same time, Shuttle America was transitioning to the smaller Dash 8-100 and started taking deliveries of former Chautauqua Saab 340 aircraft.

Headquarters were moved from Fort Wayne to Republic's Indianapolis base shortly afterwards, and the Saab 340 fleet was replaced by Embraer 170 aircraft operating for Delta Connection and United Express.

Republic Airways Holdings merged Shuttle America and Chautauqua Airlines by the end of 2014 to reduce costs.

On the evening of January 30, 2017, Shuttle America ceased operations and all remaining aircraft and crew were transferred to the Republic Airways Inc. certificate.

Shuttle America had five crew member bases at the time of its merger into Republic: Columbus, Chicago O'Hare, Indianapolis, Newark, and New York-LaGuardia.