In the late 19th century, Comanche children were placed in indigenous boarding schools where they were discouraged from speaking their native language, and even severely punished for doing so.

A group of seventeen young men referred to as the Comanche Code Talkers were trained, and used by the U.S. Army to send messages conveying sensitive information in the Comanche language so that it could not be deciphered by the enemy.

[6] The Comanche Language and Cultural Preservation Committee offers dictionaries and language-learning materials.

[8][9] The college previously conducted a language-recording project, as the language is "mostly oral", and emphasized instruction for tribal members.

[10] On the language-learning platform Memrise, the Comanche Nation Language Department has published learning materials.

[11] As of 2022, there were fewer than nine fluent native speakers of Comanche, many of the group having succumbed to old age, health problems, or the COVID-19 pandemic.

Long vowels are never devoiced and in the orthography they are represented as (aa, ee, ii, oo, uu, ʉʉ).

Like many languages of the Americas, Comanche first-person plural pronouns have both inclusive and exclusive forms.

The Comanche paradigm for nominal number suffixes is illustrated below (in the practical orthography): Many of the verb stems regularly are suppletive: intransitive verbs are suppletive for singular versus plural subject and transitive verbs are suppletive for singular versus plural object.

Common auxiliary verbs in Comanche include hani 'to do, make', naha 'to be, become', miʔa 'to go', and katʉ / yʉkwi 'to sit'.

For example, the English sentence 'I hit the man' could be rendered in Comanche with the components in either of the following two orders: 'I' (topic) 'man' (object) 'hit' (an aspect marker) - the standard SOV word order - or 'man' (object and topic) 'I' 'hit' (an aspect marker) - an OSV word order, which accentuates the role of the man who was hit.

In the 1956 film The Searchers, starring John Wayne, there are several badly pronounced Comanche words interspersed, such as nawyecka (nooyʉka 'move camp around') and timoway (tʉmʉʉ 'buy, trade').

In a 2013 Boston Globe article, linguist Todd McDaniels of Comanche Nation College commented on Johnny Depp's attempts to speak the Comanche language in the film The Lone Ranger, saying, "The words were there, the pronunciation was shaky but adequate.

The 2022 movie Prey, set in the early 18th century, is the first feature film to have a full Comanche language dub.