It goes back to the earlier school for boys, founded by Catholic priests from Italy in 1929.

It was managed by priests and monks, who arrived in Sudan to continue Comboni´s work in education.

[1] Since its beginning, the college catered to students both with an international background, but most of them were Sudanese children.

[2] In 1999, parents asked the management to develop a post-secondary section.

In 2001, this initiative led to the present Comboni College of Science and Technology (CCST) as a separate institution from the primary and secondary sections of Comboni College Khartoum.