Originally conceived as a vehicle for at least one first-run sitcom (thus reviving the practice of programming entertainment programs on Saturday nights for the first time in several years), the block instead became an hour for airing two in-season or previous season reruns of CBS sitcoms from the network's Monday and Thursday night lineups.

The first half-hour of the block was originally to comprise first-run episodes of Rules of Engagement, which would have moved from the Thursday time slot it held at the end of the 2010–11 television season, mainly to allow that program to build up enough episodes for syndication (by doing so, Engagement was to have become the first scripted first-run series to air on a broadcast network on Saturday night, excluding already-canceled series, since 2005).

However, Engagement's Saturday run was held back as the premiere of the new sitcom How to Be a Gentleman, which took the place of Engagement in its Thursday timeslot, struggled, and after two weeks, the network announced that Engagement would premiere and remain in that Thursday timeslot on October 20, 2011, with new episodes of Gentleman moving to the second half-hour of the Saturday block, effectively being burned off on Saturday nights without CBS actually classifying it as a canceled program (the network traditionally does not announce any official program cancellations until the May upfronts, in contrast to other American networks).

With no original programming, Comedytime Saturday consisted solely of reruns of CBS's Monday and Thursday night sitcoms (How I Met Your Mother, 2 Broke Girls, Two and a Half Men, Mike & Molly, The Big Bang Theory, or Rules of Engagement).

During part of the season, the first hour of Saturday prime time programming was used to burn off remaining episodes of the cancelled Made in Jersey.