Released as the album's lead single, it was produced by Batson.

Initially, it was released as an airplay-only single, entering the Billboard Hot R&B/Hip-Hop Songs chart at number eighty-nine the week of August 16, 2003, spending twenty weeks and in the process and peaking at number sixty.

It was nominated for two Grammy Awards in 2004: "Best Traditional R&B Vocal Performance" and "Best R&B Song".

"Comin' from Where I'm From" was remixed by Lupe Fiasco's Mixtape Fahrenheit 1/15.

Hamilton performed the song on an episode of Chappelle's Show and One on One.