Southern Comfort is the second compilation album by American singer Anthony Hamilton.

It was released on April 3, 2007, by Merovingian Music.

The album consists of previously unreleased tracks written and recorded by Hamilton between 2000 and 2002, before the release of his debut studio album, Comin' from Where I'm From—similarly to 2005's Soulife.

It was Hamilton's first album to have a Parental Advisory label.

Writing credits adapted from BMI.