The squadron was involved in a number of engagements during the Anglo-Spanish War including the action of 11 November 1779.

The Station was re-established in 1795 under the command of Vice-Admiral Sir George Vandeput to undertake convoy duties between England the Mediterranean and Lisbon.

In 1808 Vice-Admiral Sir Charles Cotton was charged with preparation of Lisbon harbor for the planned invasion of the Iberian Peninsula later in the year.

The fleet was also involved with the evacuation of Sir John Moore's army stuck in Galicia following the Battle of Corunna.

Gage was ordered, by the Admiralty, to undertake protection duties of Queen Maria II during the period known as the Liberal Wars, fought between progressive constitutionalists and authoritarian absolutists in Portugal over royal succession.