Commercial Drive is a roadway in the city of Vancouver in British Columbia, Canada, that extends from Powell Street at its northern extremity, near the waterfront, south through the heart of the Grandview–Woodland neighbourhood to the Victoria Diversion near Trout Lake.

Commercial Drive is a mixed residential-commercial area with a high proportion of ethnic and vegetarian restaurants, businesses, and public housing.

The area has low property prices compared to the westside of Vancouver, yet has good city services and is a local transit hub.

Commercial Drive has many local ethnic stores and community groups, Edwardian-style heritage buildings, European-style cafes, bars, and alternative shops and entertainment venues.

It is home to an active street festival culture; notable annual events include the Vancouver Dyke March in August and the Parade of Lost Souls in October.

During the pre-World War One period, a number of speculators—including McSpadden and Odlum (both of whom have nearby streets named for them) -- attempted to turn the Grandview neighbourhood, centered on the Drive, into a real estate area comparable to the West End and the newly opened Shaughnessy Heights.

After World War II many Italian immigrants settled in eastern Vancouver, and the northern part of Commercial Drive came to be known as "Little Italy".

In early summer 2005, Commercial Drive hosted its first car-free festival, in which 16 blocks were cleared of all vehicles and tens of thousands of people celebrated with walks, dancing, and food.

Local businesses are invited to move their production outside to the sidewalk and street for the day, creating outdoor spaces for eating and shopping.

The festival continues to celebrate Commercial Drive's Italian roots today, and does so by engaging local vendors, merchants, restaurant patios, stages with live music and theatre, street performances, activities and displays.