[5] The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease.

The overall Complement system is composed of protein groups that collaborate in destroying foreign invaders, which ultimately remove debris from cells and tissues.

It is thought that cleavage of C2 by C1s, while bound to C4b, results in a conformational rotation of C2b whereas the released C2a fragment may retain most of its original structure.

[6] In the Molecular Biology, the deficiency of Complement Component 2 i s a disorder that causes a major effect in the immune system, resulting in a form of immunodeficiency.

Using a hemolytic-plaque assay, RNA extraction, and blot analysis, it is fair to note that complement component 2 deficiency is a result of pre-translational regulatory detect in C2 gene expression.

Lupus can range from mild to severe and can cause inflammation in organs, such as joints, skin, kidneys, and brain.

C2 is an important component of both the classical and lectin pathways of complement activation, and is essential for first line defense against microbial infection.

Patients should seek for accessible resources offered by the medical provider and take the necessary actions needed to treat for complement deficiency.

C2 type I deficiency is caused by a 28-base pair gene deletion, resulting in premature termination codon and lack of C2 protein.