Thus, by limiting the amplification convertases of the complement cascade, DAF indirectly blocks the formation of the membrane attack complex.

CCP2, CCP3, CCP4 and three consecutive lysine residues in a positively charged pocket between CCP2 and CCP3 are involved in its inhibition of the alternate complement pathway.

In PNH disorder, red blood cells with very low levels of DAF and CD59 undergo complement-mediated hemolysis.

Symptoms include low red blood cell count (anemia), fatigue, and episodes of dark colored urine and other complications.

Binding of DAF to human HIV-1 when the virons are budding from the surface of infected cells protects HIV-1 from complement mediated lysis.