Compositional domain

A compositional domain in genetics is a region of DNA with a distinct guanine (G) and cytosine (C) G-C and C-G content (collectively GC content).

[1] The homogeneity of compositional domains is compared to that of the chromosome on which they reside.

[2] However, recent sequencing of complete genomic data refuted the isochoric model.

Its main predictions were: The compositional domain model describes the genome as a mosaic of short and long homogeneous and nonhomogeneous domains.

[20][21][22] The human genome was described as consisting of a mixture of compositionally nonhomogeneous domains with numerous short compositionally homogeneous domains and relatively few long ones.

Example of a hypothetical genomic sequence composed of 9 compositionally homogeneous domains used to demonstrate the model. The segmentation algorithm partitioned the sequence and correctly identified 4 domains as compositionally homogeneous domains and 2 compositionally nonhomogeneous domains. [ non-primary source needed ]