The journal was relaunched in 2025 to include research articles, reviews, and editorials.

Now, Comprehensive Physiology publishes articles in the interdisciplinary field of inter-organ communication in health and disease.

Example topics include inter-organ cellular communication, signaling pathways, organ crosstalk, systems biology, inter-organ pathology and pathogenesis, and the role of hormones and neurotransmitters.

[1] Previously, the journal consisted of invited review articles, published in quarterly issues, and includes over 30,000 pages of the APS's Handbook of Physiology series of books, scanned and presented online for the first time.

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