The second season of Brothers & Sisters consisted of only sixteen episodes due to the 2007–2008 Writers Guild of America strike.

The series was then repeated on Channel 4 in October of the same year around 4:30 pm on Saturdays, but after a couple of weeks moved it to Sunday nights in an unspecified time slot after midnight.

Rob Lowe, who portrays Robert McCallister, is upgraded to a series regular as his character prepares to marry Kitty.

This season also introduced new recurring characters Graham Finch (Steven Weber) and Isaac Marshall (Danny Glover) as love interests for Sarah and Nora respectively.

Emily Rose will also guest star as Lena Branigan; a friend of Rebecca's who starts working at Walker Landing and grows close to Tommy.

Series producer Ken Olin also guest stars as David Caplan, a film director and Holly's ex-boyfriend.

Nora enters into a new romance with Isaac Marshall (Danny Glover) after meeting him when Kitty brings him in to assist with Robert's campaign.

He suggests a risky business deal to help raise Ojai's profits, which Saul supports but Sarah is not on board until the very end.

After a confrontation with Rebecca (resulting in her moving back in with her mother) about his relationship and his medication, Justin seeks help and his brother stays with him during his withdrawal.