CiSE aims to provide its readers with practical information on the latest developments in computational methods and their applications in science and engineering.

Computing in Science & Engineering publishes peer-reviewed technical articles, special issues, editorials, and departments (regular columns).

The winner of the CiSE 2021 Best Paper Award was "Jupyter: Thinking and Storytelling With Code and Data," by Brian E. Granger and Fernando Pérez.

[10] The precursor magazine, IEEE Computational Science & Engineering (CS&E), was founded by Ahmed Sameh,[11] known for his contributions to parallel algorithms in numerical linear algebra, who remained in the CiSE board for several years.

Dianne O'Leary, emeritus professor of computer science at the University of Maryland,[12] was editor of the Your Homework Assignment column for several years starting on 2003.