Users of Comtal image processors included NASA, the military,[1] computer-aided designers, X-ray technicians, and engineers in the field of signal processing.

The foundation for the company's first products was based on research conducted on digital image processing by NASA in the 1960s at the Stennis Space Center (then known as the Mississippi Test Facility).

[6] In May 1974, the company unveiled the 8300 Series, which allowed the RGB channels to be imported and manipulated separately while adding the ability for a grayscale image to be rendered in false color.

[7] Comtal's 1977 Vision One system was dubbed by Business Screen magazine as "one of the most significant breakthroughs in the industry" due to its ability to load custom application software, negating the need for a mainframe or minicomputer.

[2] NASA employed Comtal's processors to process the first clear images from the surface of Mars as broadcast by the Viking program's space probes in 1976.