With an estimated net worth of US$3.7 billion as of October 2024, Forbes reported that she is America's second richest self-made woman born outside the US and one of the 400 wealthiest individuals in the world.

[5] She went to the United States to attend Baker University in Baldwin City, Kansas, where as a freshman she met her husband to be, Andrew Cherng, then a sophomore.

[5][8] She worked towards her PhD by developing a pattern-recognition program that digitized X-rays and applied algorithms to diagnose congenital heart disease.

[18] In February 2011, the Cherngs donated $2.5 million to support the Collins College of Hospitality Management at California State Polytechnic University, Pomona.

[21] In the following month, the University of Missouri announced receiving a $1.5 million gift from the Cherngs which would benefit its Honors College.

[22] The Cherngs donated $100 million to City of Hope in 2023 to advance cancer care that integrates Eastern and Western healing methods.

[5] In 2018, it was announced that the Cherng Family Trust purchased the former Mandarin Oriental hotel on the Las Vegas Strip and rebranded it as a Waldorf Astoria.