A comutagen is a substance that is not a mutagen by itself, but in the presence of a mutagen, enhances mutagenic activity.
[1] There are at least two manners by which this may occur; the comutagen may strengthen the mutagenic activity of mutagenic chemicals, or it can create a mutagenic response from nonmutagens.
[2] Chemicals such as harmane and norharmane (present in tobacco tar) have been identified as comutagens.
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