[5] María de la Concepción Jesusa Basilisa Rodríguez-Espina y García-Tagle was born in Santander, the seventh of 10 children of Víctor Rodríguez-Espina y Olivares and Ascensión García-Tagle y de la Vega.

On 12 January 1893 she married Ramón de la Serna y Cueto, and they moved to Valparaíso, Chile during some years.

The marriage had 5 children: Ramón, Víctor, José, Josefina (wife of Regino Sainz de la Maza) and Luis.

A Madrid metro station of line 9, Concha Espina, is named after her.

A major avenue in the same area is called Avenida de Concha Espina.