The NSW Statewide Severe Burn Injury Service and the Bernie Banton Centre, an asbestos diseases research institute, are located there.

Prior to the Second World War, the 16-hectare (40-acre) Yaralla Estate on which the hospital is built belonged to philanthropist Thomas Walker and subsequently his daughter Dame Eadith Walker.

Following the death of Dame Eadith in 1937, the property was bequeathed to the Crown for development as a public hospital.

A number of memorials maintain these links, including: During mid-2006, construction work commenced on a new mental health precinct at the northern end of the hospital grounds.

On completion the Sydney South West Area Mental Health Service (SSWAHMS) will relocate the majority of its existing services from The Rozelle Hospital to the new facilities at CRGH.