It provided future pastors with training before they attended a seminary, during their third and fourth undergraduate years of college.

Today those colleges are responsible for much of the undergraduate training of future LCMS pastors.

The campus became the home of the Concordia Theological Seminary as that institution relocated from Springfield, Illinois.

The Concordia Senior College's athletic teams were called the Saxons (named for the Lutheran immigrants from Saxony to Missouri in the late 1830s who then helped form the LCMS).

The college was a member of the National Association of Intercollegiate Athletics (NAIA), primarily competing in the Mid-Central College Conference (MCCC; now currently known as the Crossroads League since the 2012–13 school year) from 1959–60 to 1971–72, and then as an independent until the school's closure.