Conditioned satiety was first evidenced in 1955[1] in rats by the late French physiologist professor Jacques Le Magnen.
Unlike the other two sorts of stimulus-specific satiety, this phenomenon is based on classical conditioning[3][4][5] but is distinct from conditioned taste aversion (CTA) in its dependence on internal state towards the end of a meal.
Conditioned satiety is thought to be acquired when a food with a given flavour is eaten on a partly full stomach and followed promptly by a mildly aversive digestive event ("bloat").
However, it is uncertain if and how this phenomenon may occur under real-life conditions as normally more than food of one given flavor is ingested during a meal.
The particularity of conditioned satiety is that the time lapse between intake (and thus sensory stimulation) and the aversively conditioning after-effect is much shorter (less than 15 minutes) than that feasible for the conditioning of simple aversion to taste, odour or texture by poisoning, which can occur with a delay in postabsorptive effects of 12 or more hours.