[1][2] The giant Caribbean sea anemone's primary mating season is reported to be in late May; however, they may continue to reproduce at a low levels throughout the year.

The giant Caribbean sea anemone's reproduction scheme has been defined as oviparous → planktonic → lecithotrophic.

Fertilization produces a planula larva, which derives nutrients from yolk, thus larval death by starvation is unlikely, making dispersal an advantageous strategy to survival.

This approach to defense / protection allows for the surface area of these animals to be reduced enough to create less chance of a predator attacking them.

[4] The tips of the giant Caribbean sea anemones’ tentacles are packed with nematocysts that contain CgNa toxin.

A giant Caribbean sea anemone is very aggressive towards other marine aquarium invertebrates, and it usually fights to conserve its own space on the ocean floor.

It will not, however, go near any natural predators, such as red leg hermits, the grey sea slug, or the tompot blenny.