[1][2] "Cg" is an abbreviation for Condylactis gigantea, a giant Caribbean sea anemone from which the venom is isolated.
[2] The most distinctive feature in the primary structure between CgNa and its related proteins lies in its difference in the distribution of electrostatic charge; CgNa contains more negatively charged residues and a lower percentage of exposed hydrophobic residues than is typical for type I and II toxins.
[3] CgNa slows the inactivation of tetrodotoxin-sensitive sodium currents and thereby increases the action potential duration.
The toxin has an effect on the sodium channels within 1 minute of application and is partially reversible after removal and wash out.
[2] Studies using both mammalian and insect cloned Nav channels subtypes showed that CgNa expresses phylum selectivity.
[3] The inactivation effects of 10 μM application of CgNa on cultured rat dorsal ganglion neurons for 1 to 20 minutes exposure time seem to be fully reversible with repeated washout of the preparation.