The book is a parody of the Nancy Drew mystery series published under the collective pseudonym Carolyn Keene and created by Edward Stratemeyer.

The two share a deep love with one another, however Nancy chooses to remain with Ned Nickerson because he offers her stability that Frank cannot due to the danger and requirements of his military career.

[2] Melanie Rehak of The New York Times reviewed the book upon its release, writing that "Chelsea Cain's gleeful parody "Confessions of a Teen Sleuth" affectionately hits all the formulaic high points of a Nancy Drew mystery, sending up and yet saluting America's favorite girl detective.

"[3] NPR and January Magazine also reviewed Confessions of a Teen Sleuth, with the former stating "Cain's love of the Nancy Drew books and her ability to draw out and twist every ridiculous morsel from the originals combine to make for an hour or two of tremendously entertaining reading.

"[4][5] The reviewers for The Ledger were mixed, as they "were split on whether the book is an affectionate spoof or a nasty, nostalgia-wrecking insult to the world’s best-known fictional girl detective.