[2] Other symptoms include:[4] A missense or nonsense mutation to the genes that code for the fibrinogen protein are affected.

[3] In normal conditions, fibrinogen is converted to fibrin when it is cleaved by the enzyme thrombin in the blood.

[11] Although some thrombotic complications have been reported following replacement therapy, transfusions of fibrinogen concentrate are widely considered to be the most beneficial.

[5] As there is not much data out on the life expectancy of an individual with afibrinogenemia, it is difficult to determine the average lifespan.

[5] It was first described in 1920 by German doctors, Fritz Rabe and Eugene Salomon, studying a bleeding disorder presenting itself in a child from birth.

[14] Both males and females seem to be affected equally,[2] but it has a higher occurrence in regions where consanguinity is prevalent.