Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), a protein that causes blood to clot in the coagulation cascade.

[1] Symptoms may differ greatly, as apparently modifiers control to some degree the amount of FVII that is produced.

[citation needed] While in congenital disease symptoms may be present at birth or show up later, in patients with acquired FVII deficiency symptoms typically show up in later life.

[citation needed] About 3-4% of patients with FVII deficiency may also experience thrombotic episodes.

[2] In the acquired of FVII deficiency an insufficient amount of factor VII is produced by the liver due to liver disease, vitamin K deficiency, or certain medications (i.e., Coumadin).

[4] Blood tests are needed to differentiate FVII deficiency from other bleeding disorders.