Clubfoot, one of the most common congenital deformities of the lower limbs, occurs approximately 1 in 1000 births.
The prevalence of these defects in the United States is approximately 1 in 1900 births.
[2] This category includes amelia, ectrodactyly, radial dysplasia, and phocomelia among others.
These defects are more likely to be unilateral than bilateral, more likely to affect the upper limbs than lower limbs, and are associated with complex genetic syndromes about 10% of the time.
[4] Many of these abnormalities do not have an impact on function but may be useful in diagnosing genetic syndromes; for example, the single transverse palmar crease is commonly associated with Down syndrome.