Held in Panama City from 22 June to 15 July, it proposed creating a league of American republics, with a common military, a mutual defense pact, and a supranational parliamentary assembly.
The Empire of Brazil did not send delegates, because it expected a hostile reception from its Hispanic neighbours due to its ongoing war with Argentina over modern Uruguay.
The United Kingdom accepted the proposal and sent an observer, Edward James Dawkins, but with precise orders from Minister George Canning: limit themselves to seeking trade agreements and dissuade Greater Colombia and Mexico from supporting expeditions to the islands of Cuba or Puerto Rico to make them independent of Spain.
President John Quincy Adams and Secretary of State Henry Clay wanted the US to attend the congress, to which they had only been invited due to pressure on Bolívar.
Despite their eventual departure, one of the two US delegates, Richard Clough Anderson Jr., died en route to Panama; and the other, John Sergeant, arrived only after the Congress had concluded its discussions.