Conjoined gene

At present, 800 CGs have been identified in the entire human genome by different research groups across the world including Prakash et al.,[2] Akiva et al.,[3] Parra et al.,[4] Kim et al.,[5] and in the 1% of the human genome in the ENCODE pilot project.

[6] 36% of all these CGs could be validated experimentally using RT-PCR and sequencing techniques.

More than 70% of the human conjoined genes are found to be conserved across other vertebrate genomes with higher order vertebrates showing more conservation, including the closest human ancestor, chimpanzee.

There are a few web resources which include information about some CGs in addition to the other fusion genes, for example, ChimerDB and HYBRIDdb.

Another database, ConjoinG, is a comprehensive resource dedicated only to the 800 Conjoined Genes identified in the entire human genome.