It starts at Route 10 in the Mount Carmel section of Hamden heading east as Ives Street.

Route 22 then turns south on Broadway 0.2 miles (0.32 km) later, becoming Davis Road as it enters the town of North Haven.

It turns left on Ridge Road then continues east as Bishop Street towards North Haven center.

It briefly overlaps Route 17 (Middletown Avenue) as it shifts cardinal direction, heading southward along Forest Road.

[3] In 1973, a section in North Haven between State Street and Washington Avenue was rerouted from its original alignment along Broadway to the new Route 5/22 Connector, including a partial interchange with I-91 (at Exit 11).