Route 322 is a state highway in west central Connecticut, running from Wolcott to Southington.

Route 322 begins at an intersection with Route 69 in Wolcott and passes through the town center as it curves east, southeast, and south to the southeast corner of the town.

It then turns onto Meriden Road, and descends into Southington, becoming Meriden-Waterbury Turnpike.

In Southington, it continues in a generally east-southeasterly direction just north of the Southington-Cheshire town line.

The road continues into Meriden as West Main Street.