[4] Since opening in August 2018, the arena has mainly hosted music acts including Van Morrison, Jack White, The Vamps, Bob Dylan,[5] Paloma Faith, James Arthur, the Courteeners, Catfish and the Bottlemen, Two Door Cinema Club, Texas (band), Westlife, Boyzone, JLS, George Ezra, Noel Gallagher's High Flying Birds, Sean Paul, Kaiser Chiefs, The Darkness (band), Pet Shop Boys, Stereophonics, Diversity, Richard Ashcroft, Blossoms, Elbow, Frank Turner and The Sleeping Souls, The Specials, Tom Grennan, Bring Me the Horizon, Bastille, You Me at Six, The Offspring, Bullet for my Valentine, Corey Taylor, Less Than Jake and Bowling for Soup.

[6][additional citation(s) needed] Comedians who have played shows at the Connexin Live Arena include James Acaster, Jimmy Carr, Rob Beckett, Romesh Ranganathan, Micky Flanagan, Rhod Gilbert, Jack Whitehall, Michael McIntyre, Russell Howard, John Bishop and Sarah Millican.

[6][additional citation(s) needed] The Harlem Globetrotters have visited the Connexin Live Arena on two occasions, first playing on 14 October 2022 as part of the Spread Game Tour before returning on 25 February 2024 as part of the team's 2024 World Tour.

[7][8] The arena hosted its first professional wrestling event in 2019 with the visit of WWE NXT UK between 15 and 16 November.

The World Wrestling Entertainment brand had last visited Hull's Ice Arena in 2005, with the visit playing host a return for former Hull Kingston Rovers professional rugby league player Luke Menzies, going by the stage name of Ridge Holland, to the city.