[2] Connie is voiced by American actress Maya Rudolph, who has received critical acclaim for her role, winning the Primetime Emmy Award for Outstanding Character Voice-Over Performance in 2020, 2021, and 2023, alongside a further nomination in 2022.

Connie is a vibrant yellow hormone monster with long, flowing, and luscious hair and tawny brown body with fur that covers her chest, arms, legs and bottom.

In "The Head Push",[6] Connie was revealed to be Missy's hormone monstress also, and led her into playing seven minutes in heaven with Andrew at Leah's party.

Nick was confused as to why he had a female hormone monster but Connie told him not to question it and taught him how to masturbate.

In "Girls Are Angry Too", Jessi and Nick got into a fight over the school's dress code and Connie, being the hormone monster for both of them, played both sides of the argument until they eventually made up.

In "A Very Special 9/11 Episode", Nick was mad at Connie for siding with Jessi when she was in a toxic relationship with Michaelangelo.

[7] Connie failed to warn Jessi about these red flags because she, too, was blinded by his looks and couldn't see what a horrible man he truly was.

Connie appears in a spin-off in the Netflix animated Big Mouth series: Human Resources,[9] she is joined by Maury the Hormone Monster.