[1] On October 26, 2013, Shaw was unable to start because of illness and a sprained left knee but came off the bench to lead the Gamecocks from a 17-point deficit to defeat the No.

[9] In his preseason debut, he completed 8 of 9 passes for 123 yards with one touchdown and no interceptions against the Washington Redskins.

[11][12] Due to injuries to Johnny Manziel and Brian Hoyer, on December 22, 2014, Shaw was called up from the practice squad to be on the active roster.

[14] Starting against the Ravens in his first and only career NFL game, Shaw went 14/28 for 177 yards with 1 interception and 0 touchdowns, including a 49-yard pass to wide receiver Taylor Gabriel after avoiding pressure.

[15][16] On August 13, 2015, in a preseason game versus the Washington Redskins, Shaw injured multiple ligaments in his thumb, requiring surgery.

[19] The New Orleans Saints had accidentally sent out an email to the other 31 NFL teams, instead of the league office, indicating that they intended to claim Shaw off waivers.

[28] In August, prior to the start of the season, Shaw resigned due to his commitment in an undisclosed "private business" opportunity.

[29] On November 16, 2020, after the firing of Will Muschamp, Shaw was promoted to interim quarterbacks coach at South Carolina.