Quinn spent his last three seasons with the Kansas City Chiefs, the New York Jets, and the St. Louis Rams for one year each.

[1] As a junior in 2001, Quinn threw for 2,200 yards and 21 touchdowns to go along with 15 interceptions, posting a 9–4 record and helped lead Coffman to the Division I state semi-finals.

Quinn helped his team post an 8–3 record and played in the U.S. Army All-American Bowl in San Antonio, Texas.

Quinn was named the Columbus Dispatch and Ohio Capital Conference Offensive Player of the Year and was an All-State choice.

[1] Quinn was named an All-Conference player in baseball as a junior and lettered three times and was a part of the 2001 State Championship team.

[1] In the fall of 2002, Quinn received a scholarship from the University of Notre Dame, acting on a tip from fellow recruit Chinedum Ndukwe's father.

[2] Quinn accepted the offer to attend Notre Dame, where he set 36 Fighting Irish records during his four seasons with the team.

Quinn won 29 games as a starter at Notre Dame, tied with Ron Powlus and Tom Clements for the second most in school history.

However, after a 34–7 defeat to the Pittsburgh Steelers in Week 1, Frye was traded to the Seattle Seahawks for a sixth round draft pick, moving Quinn to second on the Browns' depth chart.

[27] On December 30, 2007, when Anderson hurt his pinky and wrist, Quinn made his official NFL debut in the Browns' final game of the season against the San Francisco 49ers.

[29] After leading the Browns to a 10–5 record, Derek Anderson was named the starting quarterback for the 2008 season, leaving Quinn on the sidelines once again.

[30] Though he played well, and helped the Browns build a two-touchdown lead into the third quarter, the Broncos rallied back to win, causing Quinn's first official start to end in a loss.

However, it was announced five days before their Week 10 Monday Night Football game against the Baltimore Ravens, that Quinn was once again being awarded the starting quarterback position.

Though he struggled in his first game back, as the Browns were shut out 16–0, Quinn followed it up in Week 11 with his best professional outing yet, throwing for 304 yards with 4 touchdowns against the Detroit Lions.

Quinn set a record for the Cleveland Browns that day being the only QB in franchise history to throw 3 touchdowns in one quarter.

The Browns later defeated the rival Pittsburgh Steelers knocking them out of playoff contention, Quinn's first win of 2009 as the starting quarterback.

He then made his Kansas City debut against the Baltimore Ravens on October 7, 2012, after Matt Cassel suffered a concussion.

On October 11, Cassel was ruled out for Week 6 game against the Tampa Bay Buccaneers, and Quinn got his first start as a Chief.

[42] Quinn was signed by the Rams on October 23, 2013, to back-up Kellen Clemens after starter Sam Bradford suffered a torn ACL.

In May 2021, Quinn began co-hosting FOX Sports Radio's weekday morning drive show Outkick The Coverage with Jonas Knox.

On September 20, 2021, "Outkick" was rebranded as "2 Pros and a Cup of Joe" with Brady Quinn, LaVar Arrington, and Jonas Knox as co-hosts.